| abstract |
The present invention provides a method for preparing eribulin and an intermediate thereof. Specifically, the present invention provides a preparation process of (3R)-2,4-dihalogen-3-methylbut-1-ene (compound of formula I), wherein X is a halogen such as iodine, bromine, or chlorine . Also provided is a preparation method for the compound of formula I for preparing halichondrin and derivatives thereof, such as eribulin. |