| abstract |
Provided are chimeric antigen receptor (CAR) molecules comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and an intracellular signaling domain, wherein an affinity of said binding domain to said antigen is characterized by a K D higher than 150 n M. Also provided are isolated polynucleotides and nucleic acid constructs comprising same, cells transduced with same and methods of using same. |