| abstract |
A method for altering one or more nucleic acid target sequences,comprising introducing into a first eukaryotic cell in meiosis: clustered regularly interspaced short palindromic repeats (CRISPR) associated protein 9 (Cas9) protein, or DNA or RNA encoding Cas9 (hereafter simply Cas9);and Cas9 guide RNA (gRNA) that hybridises to the target sequence(s). |