| abstract |
Disclosed herein, in certain embodiments, are methods and compositions for treating inflammatory disorders. In some embodiments, the methods comprise co-administering synergistic combinations of modulators of inflammation. The present disclosure provides a method for controlling cellular expression of a gene, the method comprising contacting a cell with an effective amount of an agent that maintains NF-κΒ activity in the cell at a resting or baseline level such that expression of the gene is controlled. The present disclosure provides a method for controlling cellular expression of a gene, the method of control comprising contacting a cell with an effective amount of an agent that antagonizes or regulates the formation of the PP2A holoenzyme such that expression of the gene is controlled. |