| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7772d503924be3e8470214fd587837d7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0817 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06043
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06156 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2014-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30ee240a52483cc3d8b846f2b284e58d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec6d3fdf8821fb1739b6235cbba62c7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d88d958169f32f24d2699bb3c2512c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abb771629a731c34dc2b7d69785df4e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f88b4291705dd3566c8b525992abe2b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7fa9acb6fd092cdbcee48e8ba93981d |
| publicationDate |
2015-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015021092-A1 |
| titleOfInvention |
Polyconjugates for delivery of rnai triggers to tumor cells in vivo |
| abstract |
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand- targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10308941-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11198765-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10927373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11708461-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11254792-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730691-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11530301-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3302503-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11780970-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019500472-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2748235-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11643509-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7009371-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10858658-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3271482-A4 |
| priorityDate |
2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |