| abstract |
The present invention relates to novel compounds of formula (I), wherein R 1 is C 1-4 alkyl; R 2 is C 1-4 alkyl, C 3-7 cycloalkyl, -CH 2 CF 3 , -CH 2 OCH 3 or heterocyclyl; R 3 is C 1-4 alkyl, -CH 2 F, -CH 2 OH or -CH 2 O(O)CH 3 ; R 4 when present is as defined in claim 1; R 5 when present is H, halo, hydroxy or C 1-6 alkoxy; A is -NH-, -O-, -S-, -SO-, -SO 2 -, -N(C 1-4 alkyl)- or -NC(O)(CH 3 )-; V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the proviso that no more than 2 of W, X, Y and Z are N, pharmaceutical compositions containing such compounds and to their use as bromodomain inhibitors. |