abstract |
The present invention relates to nucleic acid molecules comprising a double stranded region complementary to a target gene of an influenza virus, in particular dsRNA fragments specific for the NSI and NEP (NS2) genes. The mvention further relates to expression vectors, cells, compositions and transgenic non-human mammals and avians comprising the polynucleotides, as well as methods of treating or preventing influenza in a subject by administering the polynucleotide, vector, cell or composition to the subject. |