abstract |
The present invention addresses the problem of providing a method of efficiently producing mature megakaryocyte cell lines from hematopoietic precursor cells. The present invention provides a method of producing megakaryocytes from hematopoietic precursor cells, said method including (i) a step for inducing the expression of an apoptosis-inhibiting gene and a cancer gene in hematopoietic precursor cells, and culturing the cells; and (ii) a step for suppressing the expression of the apoptosis-supressing gene and the cancer gene, and culturing the cells. |