| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3c6f6ab0b69584e0bba483b29398a7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da5c8e8c3e8261efe7e698c7198681b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_213e7b98bce3a9d6be9936049694fa1a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4748 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2012-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61c4318d5eea69027c1b70a01767d5f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abb881375733a32f97cbc53a755aafde
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0737c10cb2ce275466f7fc056e65ed5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a8353d66b156792a8c456ea31933d27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01541b82baa39d05e42461d2f4096f00 |
| publicationDate |
2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013053765-A1 |
| titleOfInvention |
A non-human animal model of mucosa-associated lymphoid tissue (malt) lymphoma |
| abstract |
The present invention relates to a transgenic non-human animal whose genome comprises a polynucleotide comprising a hematopoietic stem cell-specific transcriptional regulatory sequence operatively linked to a heterologous nucleotide sequence encoding a human MALT1 protein and which recapitulates most of the features of human B-cell lymphomas, such as Mucosa-Associated Lymphoid Tissue (MALT) lymphoma or activated B-cell like Diffuse Large B-Cell Lymphoma (ABC-DLBCL). Further, the invention also relates to methods for the screening of compounds with pharmacologically relevant activities using said transgenic non-human animals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3736277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018020474-A1 |
| priorityDate |
2011-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |