Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3fd1afe3264d1076b11f3f63e282359 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92c7b9a2b32a90c0e8d26d96f1992f56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a45b63dfa87d1724f73ff13ee52a7859 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3a1f1c258dec23577a149be5466b35f |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-81 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-905 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 |
filingDate |
2012-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c1724ad8d18e9113369055e03438702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb697a33c631e415805a8a6b5824b1e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4b1b40bc0a3bd6e1944706cfc563e1d |
publicationDate |
2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2013043638-A1 |
titleOfInvention |
Monomer architecture of tal nuclease or zinc finger nuclease for dna modification |
abstract |
The present invention provides compositions and methods for targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector binding or a zinc finger domain and an I-TevI homing endonuclease cleavage domain as well as nucleic acid sequence encoding the same. The use of the I-TevI domain allows for monomer endonuclease sequences to achieve cleavage of cellular chromatin and represents an advantage over prior endonucleases which require self-dimerization, and two nucleases with appropriate spacers. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013068845-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10738289-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014118719-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016040594-A1 |
priorityDate |
2011-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |