http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013029571-A1

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filingDate 2011-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2013029571-A1
titleOfInvention Self-expandable biodegradable stent made of clad radiopaque fibers covered with biodegradable elastic foil and therapeutic agent and method of preparation thereof
abstract Self-expanding biodegradable stent comprising a base structure consisting of interlaced biodegradable fibres, characterized in that the core polymeric fibre containing an x-ray opaque filler is covered with an additional polymer, or the polymeric core fibre is provided with a uniformly dispersed x-ray opaque matter, or the polymeric core fibre is coated with a polymer in which an x-ray opaque matter is uniformly dispersed, the interlaced fibres forming the complete basic structure of the stent being also coated with a dispersion of a an x-ray opaque filler and with a polymer, said coatings forming a biodegradable foil provided on the basic structure of the stent and encapsulating an active substance, said active substance being selected from the group of substances including medicaments; proteins, enzymes/genes; stem cells or radioactive substances used for the Ideal treatment of tumors. 2. Method of manufacturing a self-expanding biodegradable stent having a base structure consisting of interlaced biodegradable fibres, characterized sn that it comprises the steps of covering the core polymeric fibre containing an x-ray opaque filler with an additional polymer, or providing the polymeric core fibre with a uniformly dispersed x-ray opaque matter, or coating the polymeric core fibre with a polymer in which an x-ray opaque matter is uniformly dispersed, followed by the step of coating the interlaced fibres forming the complete basic structure of the stent with a dispersion of a an x-ray opaque filler and with a polymer in order to provide a biodegradable foil on the basic structure of the stent, in which foil an active substance is encapsulated, in which step the stent provided with an x-ray opaque filler undergoes heat treatment and then it is coated with a biodegradable elastic foil made of x-ray opaque fibres containing a first medicament and after having been prepared in this manner the stent is subjected to heat treatment for the second time and recoated with a further, thinner biodegradable foil containing a second, different medicament.
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