| abstract |
The present invention relates to a poly (ester amide) (PEA) having a chemical formula described by structural formula (IV), wherein - m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9 - m+p+q=1 whereby m or p could be 0 - n is about 5 to about 300; (pref. 50-200) - R 1 is independently selected from the group consisting of (C 2 -C 20 ) alkylene, (C 2 -C 20 ) alkenylene, -(R 9 -CO-O-R 10 -O-CO-R 9 )-, -CHR 11 -O-CO-R 12 -COOCR 11 - and combinations thereof; - R 3 and R 4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 6 -C 10 )aryl, (C 1 -C 6 )alkyl, -(CH 2 )SH, -(CH 2 ) 2 S(CH 3 ), -CH 2 OH, -CH(OH)CH 3 , -(CH 2 ) 4 NH 3 +, --(CH 2 ) 3 NHC(=NH 2 +)NH 2 , -CH 2 COOH, -(CH 2 )COOH, -CH 2 -CO-NH 2 , -CH 2 CH 2 -CO-NH 2 , -- -CH 2 CH 2 COOH, CH 3 -CH 2 -CH(CH 3 )-, (CH 3 ) 2 -CH-CH 2 -, H 2 N-(CH 2 ) 4 -, Ph-CH 2 -, CH=C-CH 2 -, HO-p-Ph-CH 2 -, (CH 3 ) 2 -CH-, Ph-NH-, NH-(CH 2 ) 3 -C-, NH-CH=N-CH=C-CH 2 -. - R 5 is selected from the group consisting of (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene, alkyloxy or oligoethyleneglycol - R 6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); - R 7 is selected from the group consisting of (C 6 -C 10 )aryl (C 1 -C 6 )alkyl - R 8 is (CH2)4-; - R 9 or R 10 are independently selected from C 2 -C 12 alkylene or C 2 -C 12 alkenylene. - R 11 or R 12 are independently selected from H, methyl, C 2 -C 12 alkylene or C 2 -C 12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1. |