| abstract |
The present invention relates to a coating comprising at least one biodegradable polymer, wherein the polymer comprises at least one or a blend of a poly (ester amide) (PEA) having a chemical formula described by structural formula (II), wherein; R 1 is independently selected from the group consisting of (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene, -(R 9 -CO-O-R 10 -O-CO-R 9 )-, CH R 11 -O-CO-R 12 -COOCR 11 - and combinations thereof; R 3 and R 4 in a single co-monomer m or p, respectively, are independently selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 6 -C 10 )aryl, (C 1 C 6 )alkyl, -(CH 2 )SH, - (CH 2 ) 2 S(CH 3 ), CH 2 OH, -CH(OH)CH 3 , -(CH 2 ) 4 NH 3 +, ~(CH 2 ) 3 NHC(=NH 2 +)NH 2 , -CH 2 COOH, (CH 2 )COOH, -CH 2 -CO-NH 2 -CH 2 CH 2 -CO-NH 2 , - -CH 2 CH 2 COOH, CH 3 -CH 2 -CH(CH 3 )-, formula (a), HO- P -Ph-CH 2 -, (CH 3 ) 2 -CH-, Ph-NH-, NH-(CH 2 ) 3 -C-, NH-CH=N-CH=C-CH 2 -. R 5 or R 6 are independently selected from bicyclic-fragments of 1,4:3,6- dianhydrohexitols or from the group consisting of (C 2 -C 20 )alkylene, (C 2 -C 20 )alkenylene, alkyloxy, oligoethyleneglycol with a Mw ranging from 44 Da up to 700 Da, -CH 2 -CH-(CH 2 OH) 2 , CH 2 CH(OH)CH 2 whereby R 5 and R 6 are non identical. R 7 is hydrogen, (C 6 -C 10 ) aryl, (C 1 C 6 ) alkyl or a protecting group such as benzyl- or a bioactive agent; R 8 is independently (C 1 -C 20 ) alkyl or (C 2 -C 20 )alkenyl; R 9 or R 10 are independently selected from C 2 -C 12 alkylene or C 2 -C 12 alkenylene and R 11 or R 12 are independently selected from H, methyl, C 2 -C 12 alkylene or C 2 -C 12 alkenylene. |