abstract |
Provided is an adenovirus vector that expresses high levels of the REIC/Dkk-3 protein. The present invention is a DNA construct for the expression of REIC/Dkk-3 DNA, said construct being obtained by linking, from the 5' end: (i) a CMV promoter; (ii) REIC/Dkk-3 DNA; (iii) a polyadenylation sequence; and (iv) an enhancer obtained by linking a telomerase reverse transcriptase (hTERT) enhancer, a SV40 enhancer, and a CMV enhancer, in that order. |