| abstract |
The present invention relates to a new family of cell-penetrating peptides, comprising an amino acid sequence X 1 LX 2 RALWRLX 3 RX 4 LWRLX 5 X 6 X 7 X 8 , wherein X 1 is beta-A or S, X 2 is F or W, X 3 is L, W, C or I, X 4 is S, A, N or T, X 5 is L or W, X6 is W or R, X 7 is K or R, and X 8 is A or none. These peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-pentrating peptides around the cargo. |