| abstract |
Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R 1 is H or CH 3 , a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R 51 , R 52 , R 53 are independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group attached, preferably to the terminal end of R 51 , R 52 , R 53 , X is O or NR 54 , where R 54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R 2 and R 3 are independently an alkyl, alkyl ether, or a substituted or non-substituted aromatic group, preferred R 2 and R 3 include methyl, ethyl, and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, and substituted and unsubstituted heterocyclic groups. Suitable substituents include aryl, amine, ether, amide, hydroxyl groups, combinations thereof and the like. In another embodiment, L comprises a straight or branched alkylene group having 2 to 12 carbons. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-biologic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices. |