| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44134bcd5f90bdb1af59be62b02abf9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6b2e7ce7a23ad839e84b5e712d65d38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9ee62aaf530d08ef9977635658761d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbf98d9dc37e660844da990c0a684062 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
2010-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53e431c04d554cd49d4ab68c6fbd2612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77967d71b1ae197d279ef86682140c89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f878230566820d02fdb9316eb2107c7 |
| publicationDate |
2012-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012017443-A1 |
| titleOfInvention |
Process for preparation of highly pure dialkyl pemetrexed |
| abstract |
The invention discloses a process for preparation of highly pure dialkyl pemetrexed by reacting a 2-(4-hydroxy-6-aminopyrrolo(2,3-d)pyrimidin-3-yl)ethylbenzoic acid with a glutamatic acid diester or its salt in presence of a safe, mild, inexpensive, non-oxidative and easy to handle reagent such as substituted triphenyl phosphate. The invention further discloses purification of dialkyl pemetrexed by crystallization or trituration and conversion of purified dialkyl pemetrexed to pemetrexed or its disodium salt. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012245349-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9051322-B2 |
| priorityDate |
2010-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |