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filingDate 2011-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2012-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2012245349-A1
titleOfInvention Process for the production of a pemetrexed salt
abstract A process of making a pemetrexed salt comprising:n a) reacting a compound of formula II nn n n n n n n n n n or an acid salt thereof, wherein each of R 1 and R 2 is independently a C1-C6 alkyl group, with an aqueous basic solution at a temperature of no more than 10° C. to obtain a first mixture comprising the pemetrexed salt;n b) isolating the pemetrexed salt from the first mixture.
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