| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1dacf385e92f18cab65372306443ef2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47e6d64f3ca7f88ca5541672f0e21dca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_884a37018fc13e4a7530902ed6e0880e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b47828afb7907039447308a2ae30326
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_057f43a990dd12cbf1e4fe175cf70386 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M36-14 |
| filingDate |
2011-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_845cb27fc8e4841d43fb257797651343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f0a426bcb2ec268ae8d2d7ee06233f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_929d6eb6906fd4dfcd5aaf9be9fdb890
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b8826cee70c1e0a427507c242a43fa6 |
| publicationDate |
2012-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012012282-A1 |
| titleOfInvention |
Bifunctional rho kinase inhibitor compounds, composition and use |
| abstract |
This invention relates to synthetic bifunctional compounds comprising a first rho-associated kinase (ROCK) inhibiting compound and a second pharmaceutically active compound with complementary activity; the first and the second compounds are covalently linked by a biologically labile bond. This invention also relates to methods of making such compounds. The invention also relates to methods of using such bifunctional compounds in the prevention or treatment of diseases or conditions that are affected or can be assisted by altering the integrity or rearrangement of the cytoskeleton. Particularly, this invention relates to methods of treating ophthalmic diseases such as disorders in which intraocular pressure is elevated, for example primary open-angle glaucoma, using the bifunctional compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014174747-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104822676-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10426783-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104822676-B |
| priorityDate |
2010-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |