| abstract |
The present invention relates to novel kinase inhibitors, more particularly ROCK inhibitors, compositions, especially medicaments, comprising such inhibitors, and the use of said inhibitors in the treatment and prevention of diseases. In particular, the present invention relates to novel ROCK inhibitors, compositions, in particular medicaments, comprising such inhibitors, and the use of said inhibitors in the treatment and prevention of diseases. In addition, the invention relates to methods of treatment and the use of said compounds for the preparation of medicaments for a number of therapeutic indications, including sexual dysfunction, inflammatory diseases, eye diseases and respiratory diseases. The compounds of the present invention exhibit soft drug characteristics, ie they are rapidly inactivated after entering the systemic circulation. Thus, they allow reduced systemic exposure to functionally active ROCK inhibitors. |