| abstract |
The present invention relates to core-shell nanoparticles comprising: a manganese-containing magnetic nanoparticle (Mn-MNP) multi-core; and a silica shell coating the multi-core. Since the core-shell nanoparticles used in the present invention have high saturation magnetization (M s ) value and transverse relaxivity (R 2 ), a sensor of the present invention using the same can detect analytes with remarkably improved sensitivity. It is possible to detect a trace amount of analytes, for example, a protein or a nucleic acid molecule as an anti-cancer marker in the blood, a chemical material, and the like with the improved sensitivity. Therefore, the core-shell nanoparticles of the present invention can be useful in an effective and practical magnetic nanoparticle system and a magnetic sensing method or a contrast medium using the same due to excellent magnetic characteristics, in vivo non-toxicity, high solubility and easy surface modification. |