| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc322749b908ee63ca37a6f1c7671ab8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_139e3a98bbf68a93c1046a806cb217c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03dbd4a28db5f9da3f2809b3d31f66cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ae8cc703b9f93659319b6921b784d82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a7d60161381a8b7399ddb779e734a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_171f0ca9ca50c0ae6c723498e6cc6e15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F30-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F7-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B5-10 |
| filingDate |
2011-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3004dff9a2207c2bb32837bd8220767e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6de82ce168477de7d06aecff4e917eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b87c84ab1388ed760acc55e6dfa2e37e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4ba990728be7394644a8baae11f6341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_899ec9d0a5dd279b073aca8ea8b53f7e |
| publicationDate |
2011-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011097574-A1 |
| titleOfInvention |
Model and methods for identifying points of action in electrically active cells |
| abstract |
The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10935541-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8828721-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835168-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9650606-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163216-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9267936-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11614437-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103310040-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103310040-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9404140-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10386360-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10266804-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9489474-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8815584-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9952204-B2 |
| priorityDate |
2010-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |