| abstract |
Febuxostat can be prepared from the compound of the following formula (VI); Formula (VI) has been prepared in a one-pot process by combining a compound of the following formula (II); with an organic solvent, isobutyl halide and an inorganic base, to obtain a compound of the following formula (III); Formula III is optionally filtered before combining it with hydroxylamine base or hydroxylamine HCl. A water scavenger is added to obtain the compound of formula VI. Febuxostat can then be prepared, for example, by combining the compound of formula VI with one organic solvent and an alkali metal hydroxide. |