| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b74f9ae200789f4e85ed1743bb8663de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3acf8670babc0ba801847640e53121c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31722982d016dbd2e868e8df1339d5d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5dcbf42951a6830bcfa0e04af921a6f8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-03006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 |
| filingDate |
2010-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22637b215055e7ed413bf20ba9921e2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60a113c73f87e0306aa9ace5372b4d19 |
| publicationDate |
2011-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011029696-A1 |
| titleOfInvention |
Directed evolution of arginine deiminase for increased activity at physiological ph |
| abstract |
The present invention relates to modified arginine deiminases exhibiting an increased activity and/or reduced K m value at a higher pH, compared to a non-modified arginine deiminase, as well as uses of these enzymes for the treatment of cancer and unwanted tumor-induced neovascularization in a cancer. The present invention further relates to a method for modifying the pH optimum of the activity of an arginine deiminase, wherein said modifying provides an increased activity of said modified arginine deiminase at a higher pH, compared to a non-modified arginine deiminase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022063178-A1 |
| priorityDate |
2009-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |