http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011012702-A1

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filingDate 2010-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_677aa3d70412ed447dff74cd9b2fc078
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publicationDate 2011-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2011012702-A1
titleOfInvention Mutant glycerol dehydrogenase (glydh) for the production of a biochemical by fermentation
abstract The present invention concerns a method for the production of 1,2-propanediol, comprising culturing a micro organism modified for an improved production of 1,2- propanediol in an appropriate culture medium and recovery of the 1,2-propanediol which may be further purified wherein the microorganism expresses a glycerol dehydrogenase (GlyDH) enzyme the inhibition of which activity by NAD+ and/or its substrate and/or its product is reduced. The present invention also relates to a mutant glycerol dehydrogenase(Gly DH) comprising at least one amino acid residue in the protein sequence of the parent enzyme replaced by a different amino acid residue at the same position wherein - the mutant enzyme has retained more than 50% of the glycerol dehydrogenase activity of the parent enzyme and - the glycerol dehydrogenase activity of the mutant GlyDH is less inhibited by NAD+ and/or by its substrate as compared to the parent enzyme and/or by its product as compared to the parent enzyme.
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