| abstract |
The present invention provides a compound a formula (I); or a pharmaceutically acceptable salt thereof, wherein: X is CH 2 , O, S or-NR 1 ; each R 1 are independently C 1-7 alkyl or C 3-8 cycloalkyl; each of R 2 and R 6 are independently hydrogen, halogen, cyano, C 1-7 alkyl, hydroxy-C 1-7 alkyl, -OR 7 , C 3-8 cycloalkyl, halo-C 1-7 alkyl or -CH 2 -NR 8 -SO 2 -R 10 ; R 3 and R 4 are independently hydrogen, halogen or cyano; R 5 is hydrogen, C 1-2 alkyl, halogen, cyano, hydroxy, hydroxy-C 1-7 alkyl, hydroxy-C 3-8 cycloalkylalkyl, C 1-7 alkoxy-C 3-3 alkyl, -OR 7 , C 6-10 aryl, heteroaryl, heterocyclyl, C 3-8 cycloalkyl, halo- C 1-7 alkyl, -NR 8 R 9 , -CH 2 NR 8 -C(O)NR 8 R 9 , -CH 2 -NR 6 -SO 2 -R 10 , -C(O)- R 10 , -SO 2 R 10 , -C(O)-NR 5 R 9 -SO 2 -NR 8 R 9 , -NR 3 C(O)-R 10 -CH 2 CN, or -NR 8 -SO 2 -R 10 . Compounds of the invention may be useful in the treatment of a disorder or disease mediated by aldosterone synthase and/or 11-beta hydroxylase (CYP1 181). |