| abstract |
Disclosed are: a therapeutic agent for pulmonary hypertension, which comprises (i) RNA that comprises a sequence composed of contiguous 15 to 30 nucleotides contained in mRNA for a gene associated with the hypertrophy of a pulmonary blood vessel tissue and a nucleotide sequence complementary to the aforementioned sequence and (ii) a liposome in which the RNA is enclosed; and others. An example of the liposome in which the RNA is to be enclosed is a liposome that comprises a composite particle composed of a lead particle comprising a cationic substance and the RNA and a lipid bilayer membrane that covers the composite particle, wherein the lipid bilayer membrane comprises, for example, a lipid derivative composed of a neutral lipid and a water-soluble substance, a fatty acid derivative, or an aliphatic hydrocarbon derivative. |