| abstract |
It is intended to provide a composition which contains a liposome having an RNA enclosed therein, wherein the RNA contains a sequence consisting of 15 to 30 consecutive bases in mRNA of a target gene relating to a disease in the eyeball and a sequence complementary to the above-described sequence, and by which the liposome reaches to the eyeball. The liposome having the RNA enclosed therein is a liposome comprising, for example, a complex particle composed of a lead particle containing a cationic lipid and a particle having the RNA as the constituents thereof and a bimolecular lipid membrane coating the complex particle. The bimolecular lipid membrane is a bimolecular lipid membrane having a neutral lipid, a lipid derivative of a water-soluble substance, a fatty acid derivative or an aliphatic hydrocarbon derivative as the constituents. |