| abstract |
Provided are a method which enables both of the structural analysis and quantitative analysis of a drug metabolite and by which comprehensive analysis can be made even on a compound having no standard or an unknown compound, and a device therefor. A method for comprehensively quantifying a metabolite by mass spectrometry, even in the case where a standard for the metabolite can be hardly obtained or the metabolite is unknown, which comprises conducting quantitative RI analysis of the metabolite and quantitative analysis on a mass chromatogram thereof obtained by mass spectrometry and, based on the relationship between the results of these analyses, correcting the ionization efficiency of the metabolite in the mass spectrometry; and a device for carrying out this method. |