| abstract |
A series of fused bicyclic thiophene and thiazole derivatives (I) which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, and wherein the thiophene or thiazole ring is fused to a six-membered carbocyclic ring containing an alpha-hydroxyketone functionality, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. |