| abstract |
The present invention relates to compositions and methods for the detecting, treating, and conducting research on ophthalmic disorders associated with photoreceptor cell death and/or retinal insult. In particular, the present invention provides compositions and methods for increasing IL-6 expression and/or activity (e.g., exogenous IL-6), activating IL-6 receptors (e.g., IL-6R, sIL6-R), activating pathway related compounds (e.g., STAT, FLIP), and/or activating related pathways (e.g., JAK/STAT pathway, TGF-β pathway, Ahr pathway) in the diagnosis, treatment, and conducting research of ophthalmic disorders associated with photoreceptor cell death and/or retinal insult (e.g., retinal detachment). |