| abstract |
The treatment of proliferative diseases involving D-cyclin and/or hematological malignancy using compounds of Formula ( I ), as well as methods for identifying D-cyclin modulators are disclosed. Wherein R1 is selected from H, C1-4alkyl, C(O)OC1-4 alkyl, C(O)C1-4 alkyl and C(O)NH C1-4 alkyl, R2 is selected from H and C1-4 alkyl, R3 is selected from H and C1-4 alkyl, or R2 and R3 are joined together along with the carbon and nitrogen atoms to which they are attached to form a piperidine ring, R4 and R5 are independently selected from H, halogen, hydroxy, C1-4 alkyl, fluoro-substituted C1-4 alkyl and C1-4 alkoxy, and X is selected from C and N. |