Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_184e9683c508a79efe77d1a1c1c9a0b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8410cc67103dababbac3f31ed37aec9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f234d636624bab46e74ebba05cd0e2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2000577519bb2b107a3e6b02752bd1a9 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
filingDate |
2008-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6eb45fcb286cd6bdf975eddd520228e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47539bbd06b25b5dd3a36dee2dc7b84c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dabb831b448c1b352f50f0edf8bf4fe |
publicationDate |
2008-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2008087643-A2 |
titleOfInvention |
Methods for enhancing the therapeutic efficacy of topoisomerase inhibitors |
abstract |
Disclosed are methods and compositions useful in identifying an E3 ubiquitin ligase inhibitor and modulating cell growth, comprising contacting a cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor, wherein the treatment with the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulates cell growth in comparison to a cell treated with the topoisomerase inhibitor alone. The present invention further provides methods for identifying and making an E3 ubiquitin ligase inhibitor. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2725103-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067473-B2 |
priorityDate |
2007-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |