| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2000577519bb2b107a3e6b02752bd1a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f234d636624bab46e74ebba05cd0e2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8410cc67103dababbac3f31ed37aec9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10e4b1416c6e66e0ade5429212414964 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4406
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N29-04 |
| filingDate |
2008-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51e79f22a1c861eaf22faa5c44cf7707
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e93e81cbff06fb2b5a7c1f65fb7081d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9dd0d85a5fc5dfada63582c9b27b1d1 |
| publicationDate |
2011-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8067473-B2 |
| titleOfInvention |
Methods for enhancing the therapeutic efficacy of topoisomerase inhibitors |
| abstract |
Disclosed are methods and compositions useful in identifying an E3 ubiquitin ligase inhibitor and modulating cell growth, comprising contacting a cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor, wherein the treatment with the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulates cell growth in comparison to a cell treated with the topoisomerase inhibitor alone. The present invention further provides methods for identifying and making an E3 ubiquitin ligase inhibitor. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9545414-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9744181-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9457036-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9018192-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871271-B2 |
| priorityDate |
2007-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |