| abstract |
The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor Vila (F VHa) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a FVlIa molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of FVIIa, FVlII, or FIX. The invention also provides a method for controlling bleeding in a mammal during surgery or trauma. |