| abstract |
The present invention concerns use of a lysosome/endosome pH increasing agent (e.g. Chloroquine (CQ)) for enhancing the cytotoxicity and/or growth inhibiting effect of a liposome encapsulated chemotherapeutic drug, for example the Stealth® encapsulated doxorubicin (DOXIL®). This enhancing effect may be obtained by concomitant or sequential administration of the agent and the drug. Further provided are methods and pharmaceutical compositions comprising a liposome encapsulating a cationic amphiphilic drug, and at least one lysosome/endosome pH increasing agent, for treatment of various diseases, specifically cancer. |