| abstract |
A novel compound having antagonist activity at the S1P3 receptor represented by the formula (I); [C(R3)2]a(W)b[C(R3)2]c[P(O)(OR3)2]d[C(V)x(OR4)y(R4)z]e wherein X is selected from the group consisting of CR3 and N; Y is selected from the group consisting of CR3 and N; Z is selected from the group consisting of CR3 and N; and at least one of X, Y and Z is N; W is NR3 or O; V is oxo or represents two H atoms; provided that when V is two H atoms, z is 0; R1 is an aryl group; R2 is an aryl group; R3 is selected from the group consisting of H and alkyl and lower alkyl; R4 is selected from the group consisting of H and alkyl; and 2 of said R3 or R4 may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; a is 0 or an integer of from 1 to 6; b is 0 or 1; c is O or an integer of from 1 to 6; d is 0 or 1; e is 0 or 1; x is 1; y is 0 or an integer of from 1 to 3; z is 0 or an integer of from 1 to 3; provided however that when d is 0, e is 1, and when e is 0, d is 1, and when y is 0, z is 1 and when z is 0, y is 1. |