abstract |
The 3-aryl-piperazin-1-yl-, 2-aryl-morpholin-4-yl- and 2-aryl-thiomorphohn-4-1- derivatives of 6,7-dialkoxyquinazoline, 6,7-dialkoxyphtalazine and 6,7-dialkoxyisoquinoline of formula I are PDE10A enzyme inhibitors useful for the treatment of neurodegenerative and psychiatric disorders. |