| abstract |
Compounds of Formula (I) wherein R1 is chosen from optionally substituted phenyl, optionally substituted furanyl, optionally substituted thienyl, optionally substituted pyridinyl, and optionally substituted quinolinyl; X is CR2; R2 is hydrogen; L is chosen from a covalent bond, -CH2, -CH=CH-, -CH2O-, -CH2NHC(O)-, and -C(O> and R3 is chosen from optionally substituted aryl and optionally substituted heteroaryl, and exhibiting ATP- utilizing enzyme inhibitory such as, protein kinases, are disclosed. Protein kinase regulated diseases include, for example, the following general disease classes : cancer, autoimmunological, metabolic, inflammatory, infection, diseases of the central nervous system, degenerative neural disease, allergy/asthma, angjogenesis, neovascularization, vasucolgenesis, cardiovascular, and the like. |