| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac5ce453d31c1da40a11f093cb801c36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49219aeb6e9731f01379b00848715c36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10e4b1416c6e66e0ade5429212414964
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5d39fe4cef4ee47ad3c01dcaee17855
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e3f538daefb645d98fec27f1b5a0e3c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate |
2007-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6634915459ba6beb8f02df21555704c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05ea6d5f139139b89c0af10d27a7f583
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8af1e7201dd7a084b4f70924a16456bd |
| publicationDate |
2007-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007098250-A3 |
| titleOfInvention |
Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate |
| abstract |
A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided. A one pot continuous process for preparing (S)-AT-OL or (S)-AT-OL mandelate comprising: a) converting (R) -AT-OL to (R/S) -AT-OL in a mixture of a Cl-8 alcohols and a C2-8 ether in presence of an acid; b) reacting the (R/S) -AT-OL with (S) - ( + ) -mandelic acid in the mixture to obtain (S)-AT-OL mandelate; and c) optionally converting the (S)-AT-OL mandelate to (S)-AT-OL. |
| priorityDate |
2006-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |