| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6636b59c3149a23a6ae7feaa3984d05f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c025cc0cce6e61f5dbfe09f915bda26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fb40ecf0b2fbf644c25eb17bf756899
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1413445ab1452a5d425064cf1785a2d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-703 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2007-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3facfdd4ef943d9dd2782189cc6012c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc0e060209517081ffebcf8bc1d38a46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b06531fb495809d393d7578a78d51313 |
| publicationDate |
2007-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007084568-A2 |
| titleOfInvention |
Heteroduplex tracking assay |
| abstract |
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus may be shifted back to CCR5- mediated entry soon after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment and clinical management of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CCR5- or CXCR4-specific strains. The diagnostic methods may be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. The methods of the invention include cell-based methods, including cell fusion assays, and molecular-based methods, including heteroduplex tracking assay, to both quantitatively and qualitatively analyze patient-derived HIV for coreceptor usage. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009115594-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008131283-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009100284-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009115594-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009100284-A2 |
| priorityDate |
2006-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |