| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00a4c426c5d903a3985566b269835b34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4cea2e42d9c767a0ec65c7dc3b760ed7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_54a68e32530e5948ca250a0f81263501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd3154e39e1023c9368c98e4fe548289
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bab996dcf38452cf17090111159b4f5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c1133c0579188d5e4c5d9bc1832273d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 |
| filingDate |
2006-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0ca195180ab3f0d35553ee16eaf46cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c54b3f646c69e88e76d6169e518935a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f66946e92602a41d1f7f29ecb2c5632
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_491f27991ba742cbe983bc3f8823a6c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5541636f1642fba27d2f1ba54cd57109
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09991077fba70cc1e5ff4248d427f284 |
| publicationDate |
2007-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2007040272-A1 |
| titleOfInvention |
Method for production of d-(4-aminomethyl)phenylalanine derivative |
| abstract |
Disclosed is a method for production of a D-(4-aminomethyl)phenylalanine derivative which is useful as an intermediate for the production of a pharmaceutical agent. The method comprises the steps of producing a 5-[(4-aminomethyl)benzyl]hydantoin derivative and hydrolyzing the resulting derivative with hydantoinase in a D-stereoselective manner. In the method, the 5-[(4-aminomethyl)benzyl]hydantoin derivative can be produced by a process in which a 5-alkoxycarbonylhydantoin derivative is reacted with a 4-aminomethylbenzyl halide derivative to yield a 5-alkoxycarbonyl-5-[(4-aminometyl)benzyl]hydantoin derivative, the resulting derivative is subjected to ester hydrolysis to yield a carboxylic acid, and the carboxylic acid is then decarbonated to yield the desired derivative. Alternatively, the 5-[(4-aminomethyl)benzyl]hydantoin derivative can also be produced by a process in which hydantoin is reacted with a 4-aminomethylbenzaldehyde derivative to yield a 5-[(4-aminomethyl)benzylidene]hydantoin derivative, and the resulting derivative is then reduced to yield the desired derivative. The method can produce the compound in a simple manner and in an industrial scale. |
| priorityDate |
2005-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |