| abstract |
The present invention relates to pharmaceutical compositions comprising benzyl(idene)-lactam derivatives of formula (I) wherein R1 is a group of the formula (G1) or (G2) depicted below, and a pharmaceutically acceptable salt or optical isomer thereof and at least one active agent selected from (a) a selective serotonin re-uptake inhibitor (SSRl), (b) an alpha-2-delta (A2D) ligand or (c) a corticotropin releasing factor (CRF) antagonist and optionally a pharmaceutically acceptable carrier. |