| abstract |
The present invention relates to optically activen3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinones andnpharmaceutically acceptable salts thereof, to processes for their preparation, tonisotopically-labeled analogs thereof, to pharmaceutical compositions comprising themnand to their medicinal use as selective antagonists of the 5-HT ID receptor. Thencompounds of the invention are useful in treating depression, obsessive-compulsivendisorder (OCD) and diseases, disorders or conditions for which a 5-HT ID receptornselective antagonist is therapeutically indicated. |