| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fadb01695654d4443aba88859d6ebac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9e9c4fd849d2c4fafc64129924d9f14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a8c8f23c5b3bfccdae3f7ee7a627299 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1255 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2005-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e407e6dd5f53cfe50a6b9068d17480d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bb714e2e3cc0e866371654aa0feeb93 |
| publicationDate |
2006-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2006036269-A2 |
| titleOfInvention |
Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof |
| abstract |
One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic β-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic Ϝ-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to 32P as the source of the therapeutic β-emissions and 67Ga as the source of the diagnostic Ϝ-emissions. Another aspect of the present invention relates to the preparation of a microsphere impregnated with a radioisotope that emits therapeutic β-particles and a radioisotope that emits diagnostic β-emitting radioisotope and a Ϝ-emitting radioistope; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, said microspheres are administered to the patient through a catheter. In another embodiment, the microsphere is combined with the radioisotopes at the site of treatment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102015000813-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102015000814-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8092492-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8083771-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11052164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8829129-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105263477-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2054894-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10792301-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2968165-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9687573-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935773-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019214841-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10434200-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2202250-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2054894-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102015000812-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105263477-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016116259-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3355314-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102114248-A |
| priorityDate |
2004-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |