| abstract |
The present invention relates to a pharmaceutical agent comprising a combination of two or more parts comprising a compound of the formula:wherein R1 represents a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; X represents a bond, or the like; m represents an integer of 0 to 3; Y represents an oxygen atom or the like; ring A represents an aromatic ring which may further have 1 to 3 substituents; n represents an integer of 1 to 8; ring B represents a nitrogen-containing 5-membered hetero ring which may further be substituted by an alkyl group; X1 represents a bond or the like; R2 represents a hydrogen atom or the like; W represents a bond or the like; R3 represents a group of the formula: -OR8 (R8 represents a hydrogen atom or a hydrocarbon group which may be substituted) or the like; or a salt thereof, said two or more parts have mutually different release rates of the compound or a salt thereof. According to the present invention, a pharmaceutical agent comprising a nitrogen containing 5-membered heterocyclic compound useful as an agent for the prophylaxis or treatment of diabetes mellitus, hyperlipidemia, impaired glucose tolerance, inflammatory diseases, arteriosclerosis and the like, which has improved sustainability of an effective blood concentration of the compound, can be provided. |