| abstract |
Controlled-leaching preparations containing a physiologically active substance unstable in acids, in particular, pulsed-leaching preparations being slight in lag time fluctuation and enhanced in reliability of leaching performance. There are disclosed controlled-leaching preparations comprising core (1) containing a physiologically active substance unstable in acids and a disintegrant and controlled-leaching coating (2) covering the core and containing a water-insoluble polymer, an enteric polymer and a fat-soluble wax. |