| abstract |
A method of enantiometrically selective nucleophilic addition reaction to carbonyl, which enables asymmetric synthesis of optically active α-hydroxy-Ϝ-keto acid esters, optically active α-hydroxy-Ϝ-amino acid esters, hydroxydiketone compounds, etc. being useful as a raw material or synthetic intermediate for the production of pharmaceutical products, agricultural chemicals, perfumes, functional polymers, etc. In this method, the nucleophilic addition reaction of enamide compound accompanied by hydroxyl (-OH) formation to carbonyl is carried out in the presence of a chiral catalyst with copper or nickel. |