| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4afb8b01aa8de7e0b24a86713b23a18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7a0514364e7a36ce2a69f8be0318316
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_570227662df58d4956574123b0bc569f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0478
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0476
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-24 |
| filingDate |
2004-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb0f0556baaa4fa83359ba832b3db27e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7893b1ecef8e1365cd5bf36a822e32b7 |
| publicationDate |
2005-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2005039648-A2 |
| titleOfInvention |
Use of metal tricarbonyl complexes as radiotherapeutic chemotoxic agents |
| abstract |
The invention relates to the use of metal tricarbonyl compounds of the general formula [M(CO),L,]', wherein M is rhenium or technetium or an isotope thereof and L is a ligand, for the preparation of a medicament for the treatment of cancer that is both radiotherapeutic and chemotoxic when a radioactive metal is used and chemotoxic when cold rhenium or macroscopic amounts of long-lived Tc-99 is used. The medicament is in particular chemotoxic by causing intrastrand linkages in DNA. In a specific embodiment at least one of L is not OH2. The invention further relates to novel compounds of the general formula IM(CO)3XIX2X3]+and their use, wherein M is rhenium or technetium or an isotope thereof and at least one of X1. X2 and X3 is a monodentate ligand; or two of X, X2 and X3 are part of a bidentate ligand and the other one is optionally a monodentate ligand. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008043148-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2007306927-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2392324-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987491-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011151399-A1 |
| priorityDate |
2003-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |