| abstract |
The present invention relates to the use of a peptide comprising the amino acid sequence F X1 W R C C L I P X2 C R X3 X4 X5 K K F X6 C wherein X1, X3, X4 and X5 are independently any amino acid and wherein X2 and X6 are independently any amino acid or absent, or a fragment thereof that has the ability to bind to a mechanosensitive ion channel, in the manufacture of a medicament for modulating a mechanosensitive ion channel. Such a peptide may be used in screening methods to identify further modulators of mechanosensitive ion channels or novel mechanosensitive ion channels. |